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1. Millar, S.A. et al. (2018) A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans. Front Pharmacol 9, 1365.
2. Russo, E.B. (2019) Cannabis and Pain. Pain Med 20 (11), 2083-2085.
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12. Schlag, A.K. et al. (2021) Cannabis based medicines and cannabis dependence: A critical review of issues and evidence. Journal of Psychopharmacology 00(0), 1-13. doi:10.1177/0269881120986393.
13. Adapa, S. et al. (2020) Cannabis Vaping–Induced Acute Pulmonary Toxicity: Case Series and Review of Literature. Journal of Investigative Medicine High Impact Case Reports 8, 1-8. doi: 10.1177/2324709620947267.
14. Sarafian, TA. et al (1999). Oxidative stress produced by marijuana smoke. An adverse effect enhanced by cannabinoids. Am J Respir Cell Mol Biol 20(6),1286-93. doi: https://doi.org/10.1165/ajrcmb.20.6.3424.
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16. Clarke, S. et al. (2020) 219 Pilot clinical and pharmacokinetic study of a water soluble nanoparticle cannabis based medicine in advanced cancer with intractable pain. Asia Pac J Clin Oncol 16 (S8), 117-118. https://doi.org/10.1111/ajco.13498.
17. Stott, C.G. et al. (2013) A phase I study to assess the single and multiple dose pharmacokinetics of THC/CBD oromucosal spray. Eur J Clin Pharmacol 69 (5), 1135-47.
18. Lichtman, A.H. et al. (2018) Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain. J Pain Symptom Manage 55 (2), 179-188.
19. Vitetta, L. et al. (2018) Route and Type of Formulation Administered Influences the Absorption and Disposition of Vitamin B12 Levels in Serum. J Funct Biomater 9 (1).
20. Therapeutic Goods Administration. Australian public assessment report for nabiximols. Available at: https://www.tga.gov.au/sites/default/files/auspar-nabiximols-130927.pdf
21. Huestis, M.A. (2007) Human cannabinoid pharmacokinetics. Chem Biodivers 4 (8), 1770-804.
22. Clarke, S. et al. (2020) Pilot Clinical and Pharmacokinetic Study of Δ9-Tetrahydrocannabinol and Cannabidiol Oro-Buccal Spray in Advanced Cancer with Uncontrolled Pain. Authorea, 1-15. https://doi.org/10.22541/au.159969847.76735495
23. Hosseini, A. et al. (2020) A phase I trial of the safety, tolerability and pharmacokinetics of cannabidiol administered as single dose oil solution and single and multiple doses of a sublingual wafer in healthy volunteers. Br J Clin Pharmacol 87 (4), 2070– 2077.
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26. Stott, C.G. et al. (2013) A phase I study to assess the effect of food on the single-dose bioavailability of the THC/CBD oromucosal spray. Eur J Clin Pharmacol 64 (4), 825-34.
27. Itin, C. et al. (2019) A meta-opinion: cannabinoids delivered to oral mucosa by a spray for systemic absorption are rather ingested into gastro-intestinal tract: the influences of fed / fasting states. Expert Opin Drug Deliv 16 (10), 1031-1035.
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29. Perucca, E. and Bialer, M. (2020) Critical Aspects Affecting Cannabidiol Oral Bioavailability and Metabolic Elimination, and Related Clinical Implications. CNS Drugs 34 (8), 795-800.
30. Birnbaum, A.K. et al. (2019) Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy. Epilepsia 60 (8), 1586-1592.
31. Taylor, L. et al. (2018) A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects. CNS Drugs 32 (11), 1053-1067.
32. Lunn, S. et al. (2019) Human Pharmacokinetic Parameters of Orally Administered Δ9-Tetrahydrocannabinol Capsules Are Altered by Fed Versus Fasted Conditions and Sex Differences. Cannabis and Cannabinoid Research 4, 255–264.
33. Crockett, J. et al. (2020) A phase 1, randomized, pharmacokinetic trial of the effect of different meal compositions, whole milk, and alcohol on cannabidiol exposure and safety in healthy subjects. Epilepsia 61 (2), 267-277.
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