Nanocelle® Innovative Drug Delivery of Large Molecules

NanoCelle® has capabilities in the following areas:

  • Biologics
  • Some poorly absorbed drugs
  • Cosmetics  

Oral administration for biologics is not currently possible.

Large molecules or biologics are proteins that have a therapeutic effect. Unlike small-molecule drugs, large-molecule drugs are complex (often consisting of >1,300 amino acids), this is often due to the poor permeability of biologics across the intestinal mucosa, and sensitivity of proteins in the gastrointestinal tract.

While many patients prefer to take medications orally for convenience, oral administration for biologics is not currently possible.

Medlab Nanocelle® of Large Molecules
NanoCelle® alternative delivery system for biologics 

Several drug delivery systems for biologics have been formulated and are being investigated for nasal and pulmonary delivery, however many have proven to be ineffective, unsuitable for large-scale manufacturing, or increase risk of an acute reaction.

Medlab has developed three non-traditional large molecules: vitamins D3, B12 (in-market), and insulin (under development).

There is a significant potential for NanoCelle® to replace injectable delivery, enabling oral delivery of vaccines or immunotherapy.

 

Drug Molecule

How NanoCelle® Works

 

NanoCelle® creates nano-sized water-soluble particles that enable optimised delivery of particles, overcoming issues with solubility, and degradation.

Meaning they can pass more easily into the bloodstream for faster absorption and metabolism whilst employ nontraditional routes of administration.

NanoCelle®

  • Creates an average particle size of 5 nm to approximately 90 nm (depending on payload).
  • Consists of an inner hydrophobic core (active agents combined with lipid carrier or itself lipid-soluble and outer hydrophilic shell (various surfactants).
  • Utilises a variety of administration routes (oro-buccal, oral, topical, nasal) for a more optimised delivery of medicine.

 

 

NanoCelle® Hydrogel program

Next generation biologic administration

 

 

Large molecules, or biologics, are proteins that have a therapeutic effect. Unlike small-molecule drugs, large-molecule drugs are complex (often consisting of >1,300 amino acids).

While many patients prefer to take medications orally for convenience, oral administration for biologics is not currently possible this is often due to the poor permeability of biologics across the intestinal mucosa, and sensitivity of proteins in the gastrointestinal tract.

Our NanoCelle® hydrogel program removes payload limitations observed in oral deliveries

  • Hydrogels are three-dimensional hydrophilic, insoluble polymeric networks that can absorb, swell, and release water-based solutions
  • NanoCelle® enables the controlled and sustained delivery of poorly soluble drugs by creating nano-sized water-soluble particles that are loaded into the hydrogel matrix
  • Hydrogels forms include:
    1. slabs
    2. membrane
    3. beads
    4. microgels (microspheres)
    5. nanogels (nanoparticles)

 

Our NanoCelle® hydrogel program aims to create a world-first: an efficacious, orally administered biologic

 

  • The NanoCelle® hydrogel program can tailor and trigger the release point to a certain pH
  • Allows for effective targeted release of medicine in a dose-controlled environment
  • Enabling large molecules to be administered orally

Additional benefits

  • Protection from bacteriophages
  • Increased survival during freezing as a cryoprotectant
  • Increase survival after exposure to the gastric solution (pH 1.5-3)

 

How hydrogels work

 

Hydrogels can be designed to swell or disintegrate under specific environmental stimuli that trigger the delivery of the API. A specific environmental stimuli (e.g. pH, ionic strength, temperature, enzyme activity) can trigger the release of any encapsulated active ingredients.

How NanoCelle® hydrogels work

  • Anionic hydrogel networks remain collapsed at low pH values, due to the presence of H-bonding interactions that keep the network compacted
  • Once pH increases above the pKa of the polymer, the polyelectrolyte chains become increasingly negatively charged, and the hydrogel swells due to electrostatic repulsion and inflow of water
  • Cationic hydrogel networks present swelling behavior opposite of anionic hydrogels