NanoCelle® – a gamechanger for human health and beyond

The application of nanotechnology in medicine offers exciting possibilities to improve and discover new drug delivery systems, therapies, diagnostics, anti-microbial techniques, and forms of cell repair. In fact, researchers keep reengineering nanoparticles to treat drug-resistant cancers.

Medlab's NanoCelle® drug delivery platform has been created to administer medicines directly into the bloodstream, without needles or pills. NanoCelle® formulation that utilises submicron particles to elaborate a standardised medicine.

Our research into nano-sized particles has spanned more than two decades and our patented technology is a gamechanger for enhancing medicines and more.

 

Medlab's sub-micron particle NanoCelle® demonstrates:

3D Image of a Medlab NanoCelle® Medicine under trial

•Enhanced bioavailability

•Micelle micro-emulsion 

•Clear, stable, water-soluble formulations

•Stability up to two years at room temperature

•Scalable - 50 mL to 1000 liters

•Dosing Flexibility: oro-buccal sprays, nasal sprays, oral gels, dermal and transdermal formulations, topical gels, topical lotions, ingestible liquids, adsorption onto solid carriers

•Applications: a wide variety of hydrophobic drugs, nutrients, oil extracts, and peptides

Other applications of NanoCelle®

Generics

Shown to lower dosage and reduce side effects in generic pharmaceuticals including statins, insulin, steroids, ACEi's and antibiotics.

Vaccines

Shown to provide a needle-free alternative to traditional vaccine delivery.

Smart Wearables

Opportunity to develop triggered release of medication within medical-related garments and "smart wearables".

 

How does NanoCelle® work?

NanoCelle® creates nano-sized water-soluble particles that carry medicine or active ingredient with 95% bioavailability, meaning they can pass directly into the bloodstream for faster absorption and metabolism.

Traditional oral drug delivery relies on the active ingredient being absorbed through the gastrointestinal tract and metabolized by the liver before reaching the bloodstream. NanoCelle® allows for the active ingredient to bypass the gut and instead enhances oral-buccal, intranasal, and topical or transdermal delivery directly into the bloodstream.

The most common use of NanoCelle® is to spray the inside of the cheek to reach the bloodstream via the oral-buccal membrane.

Regardless of the original solubility characteristics of the active ingredient, NanoCelle® creates water-soluble particles that are less than 100 nanometres in size with a hydrophobic core and hydrophilic shell.

NanoCelle® technology can be utilised in multiple drug delivery systems from oral-buccal, intranasal, and topical or

transdermal delivery directly into the bloodstream.

Enhancing solubility to improve absorption

The bioavailability (the percentage of active ingredient absorbed into the bloodstream) of orally administered drugs are strongly influenced by their solubility and permeability across the GIT mucosal epithelium. 

However, NanoCelle® creates water-soluble nano-sized particles that can pass directly across the oral-buccal membrane, improving the absorption and efficacy of medicines.
 

NanoCelle® applications currently in development

NanoCelle® has been applied to a wide range of ingredients including ascorbate, CoQ10, curcumin, insulin, steroids, ACE inhibitors, antibiotics and immunosuppressive agents. 
 

Particle

Particle Size (nm)

Concentration

Dosage

Ampicillin Sodium Salt (2162016AMP)- antibiotics

12.85

2 mg/mL

0.6 mg/0.3mL

Atorvastatin (1022015ATO)

11.41

10 mg/mL

3 mg/0.3mL

Atorvastatin (1232015ATO)

89.31

0.1 mg/mL

0.03 mg/0.3mL

Atorvastatin (03212017ATO)

14.4

8.3 mg/mL

2.49 mg/0.3mL

Atorvastatin (3152017ATO)

19.37

13.3 mg/mL

3.99 mg/0.3mL

Atorvastatin-25 (12142015ATO25)

14.62

1.67 mg/mL

0.5 mg/0.3mL

Atorvastatin-30 (12142015ATO30)

14.37

1.67 mg/mL

0.5 mg/0.3mL

Atorvastatin (2162016ATO)

12.71

10 mg/mL

3 mg/0.3mL

Beta-Estradiol (2162016EST)-hormones

16.43

1 mg/mL

0.3 mg/0.3mL

Fexofenadine (TelfastTM)

10.6

4 mg/mL

1.2 mg/0.3mL

Dexamethasone (2162016DEX)-hormones

13.17

2.6 mg/mL

0.78 mg/0.3mL

Insulin (1022015INS)

3.843

15 IU/mL

4.5 mg/0.3mL

Perindopril Erbumine (2162016PER)-ACEi

12.7

7 mg/mL

2.1 mg/0.3mL

Progestogen (2162016PEO)-hormones

15.48

2 mg/mL

0.6 mg/0.3mL

Rosuvastatin (1022015ROS)-statin

12.19

2 mg/mL

0.6 mg/0.3mL

Rosuvastatin (1022015ROS)-statin

12.19

2 mg/mL

0.6 mg/0.3mL

Sertraline Hydrochloride (2162016SER)-SSRI

15.21

0.5 mg/mL

0.15 mg/0.3mL

Testosterone Propionate (123015TES)-hormones

14.31

15 mg/mL

4.5 mg/0.3mL

CoQ10 (2182916CoQ10)

32.3

100 mg/mL

30 mg/0.3mL

CoQ10 (2182916CoQ10)

32.3

100 mg/mL

30 mg/0.3mL

D3

194

3333 IU/ mL

1000 IU/0.3 mL

D3 & K2 (2182016D3K2)

28

3333 IU+150mcg/0.3 mL

1000 IU+45 mcg/0.3 mL

Melatonin (2182016MEL)

23

8.3 mg/mL

2.5mg/0.3mL

Cyanocobalamin B12

24.8

3333 IU/ mL

1000 IU/0.3 mL

Methylcobalamin B12 (2182016B12)

18.9

3333 IU/ mL

1000 IU/0.3 mL

NanaBidialTM (<1:20 THC:CBD (20mg/mL CBD and less than 1mg/mL THC)

20.13 nm

8.3 mg/mL

2.5mg/0.3mL

NanaBisTM (1:1 THC:CBD (8.33mg/mL THC and 8.33mg/mL CBD)

33.33 nm

8.3 mg/mL

2.5mg/0.3mL

NanoCBD™(16.66 mg/mL CBD)

21.29 nm

16.67 mg/mL

5mg/0.3mL

NanoCelle® third party validation

Medlab partners with Particle Technology Labs Ltd (PTL) 

PTL is a premier particle technology research company and trusted advisor to the world's industry leaders in pharmaceuticals, manufacturing, defence, agriculture, food and beverage industry as well as the public sector and scientific organisations. 

PTLs’ expert analysts generate unbiased particle characterization research information and regulatory compliance. 

How will Nanotechnology progress medicine?

Nanotechnology can enhance medical delivery and therefore the efficacy of pharmaceutical, nutraceutical, and herbal medicines.

In multiple studies, NanoCelle® has demonstrated efficacy at a fraction of the dose of its tablet or liquid counterparts. This means patients don’t need to take as much medicine and are at lower risk of side effects or drug-on-drug interactions.

NanoCelle® has been used in over 100,000 units dispensed to patients and offers exciting possibilities from its application to drug delivery, therapy techniques, and diagnostic techniques.

Product Development

Medlab continues to formulate and refine better solutions using nanotechnology.

Are you looking to deliver more?

 

Get in touch to discuss how NanoCelle® could innovate your future developments.

Partner with us